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S.E.M.I. – Side Effects May Include...
Game is not Tipiaked

S.E.M.I. – Side Effects May Include...

November 20, 2025

Overview

S.E.M.I. is a cooperative online game about escaping from a special clinic. Here you and up to 3 of your feeble-minded loyal friends in the role of patients fight with the staff and other patients and find yourself in unexpected situations. Teamwork is essential, as randomized events and experimental drugs will lead your party into unpredictable mayhem. Pop pills with your friends as you cooperate to gain your freedom.

Genres

ActionIndie

Ratings & Media

Critic & player scores, screenshots and videos for S.E.M.I. – Side Effects May Include...

Source: IGDB ↗
synced 3/29/26

Storyline

S.E.M.I. is a cooperative online game about escaping from a special clinic. Here you and up to 3 of your feeble-minded loyal friends in the role of patients fight with the staff and other patients and find yourself in unexpected situations. Teamwork is essential, as randomized events and experimental drugs will lead your party into unpredictable mayhem. Pop pills with your friends as you cooperate to gain your freedom.

Studios & publishing

  • Two Horn UnicornDev · Publisher

Themes

ActionComedyParty

Game modes

Single playerMultiplayerCo-operative

Perspective

Third person

Screenshots6 shots

Official links

Steamtwohornunicorn.comTwitter / XYouTube

Status

Game is not Tipiaked

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Platforms

PC

Stores

Steam

Community

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    Steam

    S.E.M.I. – Side Effects May Include...

    View on Steam ↗

    Players right now

    2

    24-hour peak

    9

    All-time peak

    44

    Last chart update

    Mar 29, 2026, 12:37 PM

    Player peaks from community charts (approx.). Current players from Valve when available.

    Categories

    • Single-player
    • Multi-player
    • Co-op
    • Online Co-op
    • Steam Achievements
    • Full controller support
    • Custom Volume Controls
    • Playable without Timed Input
    • Stereo Sound
    • Surround Sound
    • Family Sharing

    Tags

    • Action
    • Indie

    Steam user reviews

    Mostly Positive · 37 positive / 10 negative